منابع مشابه
Minor histocompatibility antigens.
ISTOCOMPATIBILITY antigens are a group of cell H membrane alloantigens that can trigger T-lymphocyte proliferative and/or cytolytic activity in vitro and may initiate graft rejection or graft-versus-host disease (GVHD) in vivo. AB0 and related antigens, whose presence on vascular endothelial cells may provoke antibody-mediated graft rejection, are excluded from this group because they do not in...
متن کاملHuman minor histocompatibility antigens.
Disparities in minor histocompatibility antigens between HLA-matched organ and bone marrow donors and recipients create a potential risk for graft failure and graft-versus-host disease. These conditions necessitate lifelong pharmacological immunosuppression of organ and bone marrow transplant recipients. Recent technical advances have resulted in the identification of the chemical nature of the...
متن کاملHapMap scanning of novel human minor histocompatibility antigens.
Minor histocompatibility antigens (mHags) are molecular targets of allo-immunity associated with hematopoietic stem cell transplantation (HSCT) and involved in graft-versus-host disease, but they also have beneficial antitumor activity. mHags are typically defined by host SNPs that are not shared by the donor and are immunologically recognized by cytotoxic T cells isolated from post-HSCT patien...
متن کاملAbnormal response to minor histocompatibility antigens in Obese strain chickens.
Obese strain chickens, which spontaneously develop autoimmune thyroiditis, were tested for their ability to tolerate skin allografts. Several procedures known to prolong graft survival in normal strains were employed. These included the use of skin matched at the major histocompatibility locus, grafting on the day of hatching, thymectomy, and x-irradiation. A dramatic difference between the Obe...
متن کامل[Frequency of minor histocompatibility antigens among Chilean blood donors].
BACKGROUND Minor histocompatibility antigens (mHAgs) play a critical role in the immune responses associated with allogeneic stem cell transplantation, such as graft versus host disease (GVHD) and graft-versus-tumor (GVT). AIM To determine the gene frequencies of the mHAgs HA-1, HA-2 and HA-8 in Chilean Blood Bank donors. MATERIAL AND METHODS Blood from 192 blood donors was analyzed. The pr...
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ژورنال
عنوان ژورنال: Blood
سال: 1990
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v76.7.1269.bloodjournal7671269